MIDI handling issues with the Line6 HX Effects
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If the programming and channel switching of the AMP1 Mercury or Iridium Edition does not work when using a MIDI controller, the most likely reason is that an ambiguous MIDI command - or even several MIDI commands - are being sent one after the other.
HX Effects: Turn off MIDI clock and MIDI PC TX
By default, the HX Effects sends two MIDI lines: before the actual MIDI command, the sender address of the preset is sent. This must be turned off in the HX Effects, otherwise the AMP1 Mercury/Iridium Edition will not be able to process the commands: Turn off MIDI clock in the Global Settings as well as MIDI PC TX on the 3rd screen of the MIDI settings!
Patrick's quick step guide
For a quick step guide on how to make sure the AMP1 and the Line6 HX Effects work with MIDI, check out this article!